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Shoshana Yakar Selected Research

Laron Syndrome (Syndrome, Laron)

12/2021The Olfactory Receptor Gene Product, OR5H2, Modulates Endometrial Cancer Cells Proliferation via Interaction with the IGF1 Signaling Pathway.
7/2019Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer.
1/2019Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways.
1/2018Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action.
7/2013Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor.

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Shoshana Yakar Research Topics

Disease

29Neoplasms (Cancer)
12/2021 - 02/2002
23Insulin Resistance
12/2021 - 06/2003
12Type 2 Diabetes Mellitus (MODY)
03/2014 - 07/2003
9Neoplasm Metastasis (Metastasis)
03/2018 - 02/2002
8Breast Neoplasms (Breast Cancer)
06/2013 - 08/2003
6Hyperglycemia
05/2021 - 06/2003
6Body Weight (Weight, Body)
01/2020 - 04/2010
6Hyperinsulinism (Hyperinsulinemia)
01/2017 - 11/2004
6Inflammation (Inflammations)
01/2017 - 01/2009
5Laron Syndrome (Syndrome, Laron)
12/2021 - 07/2013
4Bone Resorption
01/2018 - 02/2010
4Osteoporosis
10/2013 - 09/2002
4Carcinogenesis
12/2009 - 08/2005
3Dwarfism
12/2021 - 07/2019
3Non-alcoholic Fatty Liver Disease
01/2021 - 05/2013
3Metabolic Bone Diseases (Osteopenia)
12/2020 - 03/2005
3Obesity
01/2010 - 12/2006
2Insulin-Like Growth Factor I Deficiency
12/2021 - 01/2019
2Endometrial Neoplasms (Endometrial Cancer)
12/2021 - 07/2019
2Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2020 - 11/2017
2Carcinoma (Carcinomatosis)
03/2018 - 01/2012
2Fatty Liver
11/2017 - 05/2013
2Prostatic Neoplasms (Prostate Cancer)
12/2016 - 05/2008
2Growth Disorders
04/2016 - 03/2014
2Starvation
02/2012 - 06/2004
2Hyperplasia
06/2011 - 06/2003
2Colonic Neoplasms (Colon Cancer)
12/2009 - 02/2002
2Adenocarcinoma
05/2008 - 02/2002
1Uterine Neoplasms (Uterine Cancer)
12/2021
1Osteogenesis Imperfecta (Lobstein Disease)
12/2021
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
05/2021
1Ovarian Epithelial Carcinoma
01/2021
1Arthritis (Polyarthritis)
12/2020
1Lipodystrophy
12/2020
1Lewis Lung Carcinoma
03/2018
1Liver Diseases (Liver Disease)
01/2018
1Hepatitis
01/2018
1Liver Cirrhosis (Hepatic Cirrhosis)
01/2018
1Fibrosis (Cirrhosis)
11/2017
1Fatigue
01/2016
1Microcephaly
01/2016
1Reperfusion Injury
08/2015
1Myocardial Ischemia (Ischemic Heart Diseases)
08/2015
1Alzheimer Disease (Alzheimer's Disease)
08/2015
1Weight Gain
03/2014
1Glucose Intolerance
07/2013
1Weight Loss (Weight Reduction)
02/2012

Drug/Important Bio-Agent (IBA)

37Insulin-Like Growth Factor I (IGF-1)IBA
01/2020 - 02/2002
23Insulin (Novolin)FDA Link
12/2021 - 07/2003
12Glucose (Dextrose)FDA LinkGeneric
01/2018 - 06/2003
10Growth Hormone (Somatotropin)IBA
01/2021 - 10/2003
10IGF Type 1 Receptor (IGF 1 Receptor)IBA
07/2009 - 07/2003
9Insulin-Like PeptidesIBA
01/2021 - 08/2005
6Proteins (Proteins, Gene)FDA Link
12/2021 - 06/2002
6LipidsIBA
11/2017 - 07/2003
5Messenger RNA (mRNA)IBA
12/2021 - 10/2003
5LigandsIBA
03/2018 - 08/2005
4Somatotropin Receptors (Growth Hormone Receptor)IBA
12/2021 - 06/2011
4Insulin-Like Growth Factor Binding Protein 3IBA
01/2019 - 09/2002
4Triglycerides (Triacylglycerol)IBA
08/2015 - 10/2003
3CytokinesIBA
01/2017 - 01/2009
3Estrogens (Estrogen)FDA Link
01/2016 - 12/2006
3AcidsIBA
01/2016 - 10/2003
3Tumor Viral Antigens (Large T Antigen)IBA
12/2010 - 08/2003
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2018 - 02/2002
2Reactive Oxygen Species (Oxygen Radicals)IBA
01/2018 - 08/2015
2OsteoprotegerinIBA
01/2017 - 12/2016
2Insulin-Like Growth Factor II (Somatomedin A)IBA
01/2016 - 08/2005
2Insulin-Like Growth Factor Binding ProteinsIBA
01/2016 - 08/2005
2Insulin ReceptorIBA
06/2013 - 09/2005
2Transcription Factors (Transcription Factor)IBA
05/2013 - 01/2012
2CarbohydratesIBA
01/2012 - 12/2010
2Blood Glucose (Blood Sugar)IBA
03/2007 - 01/2004
2Hormones (Hormone)IBA
12/2006 - 11/2005
1Odorant Receptors (Odorant Receptor)IBA
12/2021
1ORALIT (ORS)IBA
12/2021
1CollagenIBA
12/2020
1Matrix Metalloproteinase 14 (MT1-MMP)IBA
12/2020
1Prolactin Receptors (Prolactin Receptor)IBA
01/2020
1Biological ProductsIBA
07/2019
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
03/2018
1ArginaseIBA
03/2018
1Nitric Oxide (Nitrogen Monoxide)FDA Link
03/2018
1Parathyroid Hormone (Parathormone)IBA
01/2017
1prostatic acid phosphataseIBA
12/2016
1RANK LigandIBA
12/2016
1Silver Sulfadiazine (SSD)FDA LinkGeneric
04/2016
1CaspasesIBA
01/2016
1Metalloproteases (Metalloproteinases)IBA
01/2016
1Blood Proteins (Serum Proteins)IBA
01/2016
1Peptides (Polypeptides)IBA
08/2015
1humaninIBA
08/2015
1Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
03/2014
1VimentinIBA
06/2013
1Doxycycline (Periostat)FDA LinkGeneric
06/2013
1Drinking WaterIBA
06/2013
1MicroRNAs (MicroRNA)IBA
05/2013
1AMP-Activated Protein KinasesIBA
02/2012
1Adenosine Triphosphate (ATP)IBA
02/2012

Therapy/Procedure

7Therapeutics
12/2021 - 09/2005